Orlistat is a weight loss medication that helps individuals reduce the amount of fat absorbed from the diet. It works by blocking the action of a digestive enzyme called lipase, which is responsible for breaking down fat in the intestines. By reducing the amount of fat absorbed, Orlistat helps people achieve and maintain weight loss. It is intended for use in combination with a reduced-calorie diet and regular physical activity. This medication is typically prescribed for people who have a body mass index (BMI) of 30 or more, or for those with a BMI of 27 or more and additional weight-related health problems. It is not recommended for individuals who are pregnant or nursing.